Over 600 known connective tissue disorders exist today
This group of inherited disorders are caused by a lysosomal enzyme deficiency. The body does not produce any, or very little, enzyme, so complex sugars are stored in the body tissue instead of being broken down and used by the body. These complex sugars are called polysaccharides, which is how this disorder gets its name.
MPS is a progressive disorder, although that progress may be slow. Some children have progressive MPS storage in the brain, which can be impact intellectual functioning and in some progress to epilepsy.
Most children with various type of MPS have very tight joints (joint contractures), but some have very loose joints (joint hypermobility). These children are managed jointly with the Department of Genetic Metabolic Medicine through the Lysosomal Disorders Management Clinic.